Dr. Kamala K. Vasu

General information
Designation:	Assistant Director Dean of Students’ Affairs & Head,
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Brief about you

Dr. Kamala K. Vasu is Assistant Director, Dean of Student's Affairs and Head Department of Medicinal Chemistry. She has more than 28 years of research experience. She did her master’s and doctorate in Organic Chemistry from Osmania University, Hyderabad. Later she had been to Academia Sinica, Taipei, Taiwan for her Post Doctoral research work.

Her research interests are in the design and synthesis of NCEs for specific therapeutic areas like, for cancer, diabetes, Alzheimer's Disease , adenosine receptors and inflammation.

Her group has synthesized many novel thiazoles, thiophenes, imidzoles, quinazoline derivatives and screened for their activity. Many of the molecules were as potential NF-kB and AP-1 transcriptional expression inhibitors implicated in autoimmune diseases and cancer and also as adenosine receptor antagonists. She is also working in impurity profiling and synthesis of the impurities and in CADD and established the same in the institute

Outcome of her research has resulted in US and European patents and many international publications in peer review journals. In addition she has also filed for five Indian Patents and more than 55 more publications in peer reviewed journals.

She has collaborations with Lousiana State University, USA, Wurzberg University , Germany.

She has been teaching both undergraduates and the post graduate students. She has guided sixteen students for their Ph. D thesis and four are presently working. She has guided more than 30 M. Pharm. students for their project work. She has also given summer training to a number students from Gujarat and other states.

She has given a number invited lectures both in Gujarat and in other states. She has received many grants from Government and from Industries.

Basic Research

• Cancer: More than 600 NCEs screened for their anticancer activity as inhibitors of NF- kB and AP-1 transcription factors. PMCR 242, a potential lead against prostate cancer is undergoing preclinical trials at LSU, USA. A collaborative project with Louisiana State University, USA.
• Identification of novel ligands for Adenosine Receptors with selectivity for A1, A2A and A3 receptors- A collaborative work with Prof. Karl-Norbert Klotz, Germany. The above work has lead discovery of potent active and lead molecules like PMCDP-T2B7, PMCDP-T2B16, PMCDP-T2B21 and PMCDP-T2B22 against Parkinson’s diseases, Asthma, Alzheimer’s Disease, Inflammation and further development is in process.
• Further more than 10 molecules with very good anti-cancer activity especially active against chemo sensitizing and chemo resistant strains. Developed in the institute.
• Radioprotective agent: Developed a novel lead molecule as the radio protecting active molecule. There is only one drug Amifostene used for patients undergoing radiation therapy. Developed within the institute.

Applied Research

• Impurity profiling and Stress degradation studies of Active Pharmaceutical Ingredients and their Formulations [Doxofylline, Trandrolapril, Irbesartan and PMCR-242 (in house product), Actarit, Bambuterol, Imidapril were carried out as per standard ICH guidelines].
• Separation, identification and characterization of impurities.
• Pharmacokinetic studies of bulk drug and in house lead molecules.
• Bio analytical method development and validation of combination of drugs.
• Stress degradation studies of herbal drugs and their formulations.

Current Activities

• Dr. Kamala K. Vasu is Assistant Director, Dean of Student's Affairs and Head Department of Medicinal Chemistry. She has more than 28 years of research experience. She did her master’s and doctorate in Organic Chemistry from Osmania University, Hyderabad. Later she had been to Academia Sinica, Taipei, Taiwan for her Post Doctoral research work.
• Her research interests are in the design and synthesis of NCEs for specific therapeutic areas like, for cancer, diabetes, Alzheimer's Disease , adenosine receptors and inflammation.
• Her group has synthesized many novel thiazoles, thiophenes, imidzoles, quinazoline derivatives and screened for their activity. Many of the molecules were as potential NF-kB and AP-1 transcriptional expression inhibitors implicated in autoimmune diseases and cancer and also as adenosine receptor antagonists.
• She is also working in impurity profiling and synthesis of the impurities and in CADD and established the same in the institute
• As Dean of Student's Affairs, taking care of all the aspects right from admission of students for their Ph.D till their thesis submission. Catering to the need of the students from other Universities for their dissertation work and summer training programs.
• As Purchase In charge looking into the smooth functioning of the system.
• Safety and disaster management in charge. In charge of women safety cell.

Experience
Research	28 years
Teaching	10 years
Industry	1 year

Contact
Website	perdcentre.com
Membership	American Chemical Society, Indian Pharmaceutical Association

Specialization
Specialization Areas:	Organic Chemistry / Medicinal Chemistry and Analytical Chemistry
Subject Taught UG:	Organic reaction mechanisms, spectroscopy, topics in Physical chemistry like chemical kinetics, chemical equilibrium
Subject Taught PG:	Basis of drug action, spectroscopy, stereochemistry, logic in organic synthesis, separation techniques, chiral separation, molecular docking and QSAR, chemistry of biomolecules, peptidomimetics.